Endocrine Abstracts

Background: Although anaplastic thyroid cancer (ATC) is found in less than 2% of patients with thyroid cancer, it is the most advanced, aggressive and lethal. ATC is known to develop from well-differentiated thyroid cancers, such as follicular thyroid cancer, and it is undifferentiated itself. Among the thyroid-specific transcription factors that are critical for the function of thyroid, the expression of thyroid transcription factor 1 (TTF1), or NKX2.1, has been reported to c...

Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. We report here a new series of allosteric PDK4 inhibitor modified from hit anthraquinone. A novel PDK4 inhibitor, namely compound 8c, improved glucose tolerance in diet-induced obese mice. PDH activity in muscle and liver was enhance d by compound 8c treatment. Given the importance of PDK4 in immune cells including mast cel...

Object: FSTL1, an extracellular glycoprotein, is a novel myokine that is secreted by skeletal muscle. However, its functions in metabolism remain unclear, Adipose tissue is one of the important organs for maintaining energy homeostasis. FSTL1 is known to induce inflammatory response and inhibit insulin-mediated Akt signaling pathway, we aimed to investigate whether FSTL1 play metabolic roles in human adipose tissue. We hypothesized that FSTL1 increases lipolysis throu...

Objective: Triglyceride glucose (TyG) index is considered a surrogate marker of insulin resistance, and insulin resistance is known risk factor of cardiovascular disease. Until now, few studies have investigated the relationship between TyG index and coronary artery calcification (CAC), thus we investigated the correlation between TyG index and CAC in healthy Korean Adults.Methods: A total of 4,463 participants underwent cardiac computed tomography in he...

Objective: Bacalin was known as an allosteric modulator of the benzodiazepine sites of the γ-aminobutyric acid A receptor (GABAAR), which produce anxiolytic effects in mice without myorelaxant or sedative effects. Baicalin occur flavonoid found in naturally in the genus Scutellaria. It has been recently shown to exert metabolic effects by attenuating hyperglycemia-induced mitochondrial damage in β-cells in diabetic rats, high-fat diet- (HFD-) indu...

Objective: Ginsenoside or saponin, is considered as the major bioactive component mediating the therapeutic properties of Korean red ginseng (KRG). However, the exact physiological mechanism underlying anti-diabetic effects is still not fully Clarified. More than 30 different saponins together account for only about 3–4% of KRG, thereby, it is assumed that non-saponin fraction of KRG also carry potential anti-diabetic effects; however, there is no study reporting the diff...

Renal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor-gamma (PPARγ) agonists have a protective effect on diabetic nephropathy, much less is known about their direct effects in renal fibrosis. This study aimed to investigate possible beneficial effects of lobeglitazone, a novel PPARγ agonist, on renal fibrosis in mice with unilateral uret...

Objective: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients and assessed their possible role as a diagnostic tool for diabetic nephropathy.Methods: Four hundred-seventy patients with type 2 diabetes were included in this study. Hemorheologic parameters, including erythrocyte deform...

Objective: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients and assessed their possible role as a diagnostic tool for diabetic nephropathy.Methods: Four hundred-seventy patients with type 2 diabetes were included in this study. Hemorheologic parameters, including erythrocyte deform...

Background: Associations between obesity and adipomyokines, inflammatory marker, and level of physical fitness have not been well evaluated in severe obesity in children and adolescents.Method: Data on leptin, irisin, FGF21, hsCRP, glucose, insulin, physical fitness measured by arm curl test for upper extremity)and wall sit test for lower extremity were obtained in 266 participants who were recruited for ICAAN study, community- based multidisciplinary we...